Ph.D. Program in Plant Molecular Biology

Friday Seminar by Dr. Adwaita Parida

AKS Lab/ Friday/ August 10, 2018/ 3.30 pm/ Circular RNA : The Biogenesis, Function and Challenges.
Category: Research

Circular RNA: The Biogenesis, Functions, and Challenges


Circular RNAs (circRNAs) are a class of newly identified covalently closed circular RNAs that are generated by alternative circularization. They were initially identified in plant viroids. The circular RNA lacks the 5’ cap and 3’ polyA tail and is resistance to exonucleases. With the expansion of high-throughput sequencing and bioinformatics in the last few years, circRNAs have been shown to be extensively distributed in eukaryotes. The circular RNAs were generated from mRNA through a splicing event involving head to tail back splicing. Some of the functions of circular RNA are known in mammals. The circular RNA acts as a miRNA sponge and protect the mRNA degradation. They are also involved in transcriptional regulation. The circular RNA was considered as a non-coding RNA, but a recent study suggests the translation of circular RNA in mammals. The ability of circular RNA to produce protein suggests the existence of an unexplored layer of gene activity.