Jitendra P. Khurana

Friday Seminar by Dr. Neelam Sarkar

AG Lab/Friday/November10, 2017/3.30 pm/ Protein Quality Control : A to Z of the PQC
Category: Research
Posted by: bedineel

Title: Protein Quality Control: A to Z of the PQC


Protein quality control, known as proteostasis, is fundamental aspect of the health of the cellular proteome. It constitutes the regulation of protein synthesis, folding, unfolding and turnover.  It is mediated by chaperones and proteases along with cellular clearance mechanisms such as autophagy and lysosomal degradation. Proteostasis is an evolutionary conserved process in cells from bacteria to humans. Imbalance in proteostasis leads to protein aggregation and successful proteostasis is the detection and removal of misfolded proteins by quality control pathways. The Casein lytic proteinase/heat shock protein100 (Clp/Hsp100) proteins are ATP dependent chaperones belonging to the AAA family of proteins that act to remodel/disassemble protein complexes and/or protein aggregates. Cytosolic AtHsp101 has a unique role in acquired thermotolerance and that a chloroplast-targeted ClpB is essential for chloroplast development and seedling viability. ZEITLUPE (ZTL) E3 ubiquitin ligase, a central circadian clock component in Arabidopsis mediates the clearance of denatured protein aggregates under heat stress conditions, thereby enhancing thermotolerance and the thermal stability of the circadian clock.