2020 Ph.D. Admissions (Interview List)

Friday Seminar by Ms. Barkha Ravi

GKP Lab/ Friday/ December 13, 2019/ 3.30 pm/ Calcium mediated active release of endogenous danger peptides to elicit defense response in plants
Category: Research
Posted by: bedineel


Calcium mediated active release of endogenous danger peptides to elicit defense response in plants


Physical trauma on plants can be provoked by various factors such as insects chewing, animal feeding, trampling or even damage due to weather. From damaged plant cells, a multitude of cellular constituents that acts as a signaling factor are released to alert and activate defense signaling events in surrounding tissue. These signaling factors, or damage-associated molecular patterns (DAMPS), includes cell-derived molecules, peptides, glutamate and many more. In Arabidopsis thaliana plants elicitor peptides (Peps) also known as “Danger peptides” were proposed to act as DAMPs and release of these immunomodulatory peptides results defense responses in plants. However, riveting is the mechanism through which this defense response is executed. Undoubtedly this mechanism has to be tightly regulated and highly secured to prevent any aberrant immune stimulation response and therefore it is mediated by Calcium as a secondary messenger. Ca2+ levels in cytosol activates metacaspases, leading to the cleavage and release of Pep1 from its precursor PROPEP1 and hence binds and activates the extracellular Pep receptors (PEPRs).  This multicomponent system can be used to improve disease resistance of high-performance crop varieties and its ameliorative effect may rescue increased crop loss due to insect pests.
  1. Hander, T., Fernández-Fernández, Á. D., Kumpf, R. P., Willems, P., Schatowitz, H., Rombaut, D., ... & Gonçalves, A. (2019). Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides. Science, 363(6433), eaar7486.


  1. Yamaguchi, Y., Huffaker, A., Bryan, A. C., Tax, F. E., & Ryan, C. A. (2010). PEPR2 is a second receptor for the Pep1 and Pep2 peptides and contributes to defense responses in Arabidopsis. The Plant Cell, 22(2), 508-522.


  1. Tang, J., Han, Z., Sun, Y., Zhang, H., Gong, X., & Chai, J. (2015). Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1. Cell research, 25(1), 110.


  1. Huffaker, A., Pearce, G., & Ryan, C. A. (2006). An endogenous peptide signal in Arabidopsis activates components of the innate immune response. Proceedings of the National Academy of Sciences, 103(26), 10098-10103.