Sanjay Kapoor

Friday seminar by Ms. Shipra Singh


JPK Lab/ Friday/ June14, 2019/ 3.30 p.m./ A Decade of TZP
Category: Research
Posted by: bedineel

 

A Decade of TZP

Shipra Singh

A new component of the photomorphogenesis in Arabidopsis thaliana, TZP (tandem zinc knuckle/PLUS3 domain protein) was first defined in 2008 by Loudet et al. through QTL analyses. It is a large, nuclear-localized protein, encoded by a single copy gene in the vascular plant lineage.  Further studies by the same group revealed that TZP directly interacts with the red-light receptor phytochrome B (phyB) in nuclear photobodies (NB) which are the sites of active transcription. They also elucidated the role of TZP along with phyB in promoting flowering by direct activation of FT gene expression. Moreover, a latest paper by the group talks about the transcription factor, ZINC-FINGER HOMEODOMAIN 10 (ZFHD10) as an interacting partner of TZP and how they together regulate common growth-promoting gene targets by associating with common promoter elements of transcriptional regulators, light-responsive and growth-promoting genes required for hypocotyl elongation. So, their studies elucidated the role of TZP as an integrator of light and photoperiodic signaling in Arabidopsis.

 

Suggested readings-

  • Loudet O, et al. (2008) A zinc knuckle protein that negatively controls morning-specific growth in    Arabidopsis thaliana. Proc Natl Acad Sci USA 105:17193–17198.
  • Kaiserli E, et al. (2015) Integration of light and photoperiodic signaling in transcriptional nuclear foci. Dev Cell 35:311–321.
  • Perrela G, et al. (2018) ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis. Proc Natl Acad Sci USA 115(19):503–511.