2020 Ph.D. Admissions (Interview List)

Friday Seminar by Ms. Lisha Khungar


AG Lab/ Friday/ December 6, 2019/3.30 pm/ HIN1: A link between drought acclimation and splicing efficiency
Category: Education
Posted by: bedineel

HIN1: A link between drought accilimation and splicing efficiency

 


Eukaryotic pre-mRNAs undergo splicing to precisely remove introns for producing mature protein coding transcript. In other cases, the process of splicing may be variable such that an intron may not always be excised leading to intron retention (IR). Unfavourable conditions or stresses such as heat, salt etc. have been linked with events of increase in IR for various transcripts. A recent research article reports observation of increase in splicing efficiency or decrease in IR in Arabidopsis thaliana seedlings treated with low water potential (Ψw). Ectopic expression of HIN1 (Highly ABA-Induced 1- Interacting Protein 1), a newly identified protein from A. thaliana also shows increased splicing efficiency in unstressed plants for one-third of the sites showing decreased IR in Ψw treated Arabidopsis plants. HIN1 interacts with HAI1, a clade A protein phosphatase 2C member involved in abiotic stress and abscisic acid signaling, and its over-expression enhances growth maintenance during Ψw.

The talk will focus on the identification of HIN1, its role in drought acclimation and how it connects stress signaling to splicing regulation!

 

References:

  • Chong, G. L., Foo, M. H., Lin, W. D., Wong, M. M., & Verslues, P. E. (2019). Highly ABA-Induced 1 (HAI1)-Interacting protein HIN1 and drought acclimation-enhanced splicing efficiency at intron retention sites. Proceedings of the National Academy of Sciences116(44), 22376-22385.
  • Bhaskara, G. B., Nguyen, T. T., & Verslues, P. E. (2012). Unique drought resistance functions of the highly ABA-induced clade A protein phosphatase 2Cs. Plant physiology160(1), 379-395.

.